Thyroid: Oncocytic tumors
نویسندگان
چکیده
منابع مشابه
Cardiolipins Are Biomarkers of Mitochondria-Rich Thyroid Oncocytic Tumors.
Oncocytic tumors are characterized by an excessive eosinophilic, granular cytoplasm due to aberrant accumulation of mitochondria. Mutations in mitochondrial DNA occur in oncocytic thyroid tumors, but there is no information about their lipid composition, which might reveal candidate theranostic molecules. Here, we used desorption electrospray ionization mass spectrometry (DESI-MS) to image and ...
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TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Materials and Methods 3.1. Tumor samples 3.2. Immunohistochemical staining and analysis 3.3. Analysis of mtDNA 4. Results and review of the literature 4.1 Renal oncocytoma 4.2 Thyroid oncocytoma 4.3 Parathyroid oncocytoma 4.4 Nasopharyngeal oncocytoma 4.5 Salivary gland oncocytoma 4.6 Adrenal gland oncocytoma 4.7 Pituitary gland oncocytoma 4.8 E...
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Oncocytic tumors are a distinctive class of proliferative lesions composed of cells with a striking degree of mitochondrial hyperplasia that are particularly frequent in the thyroid gland. To understand whether specific mitochondrial DNA (mtDNA) mutations are associated with the accumulation of mitochondria, we sequenced the entire mtDNA in 50 oncocytic lesions (45 thyroid tumors of epithelial ...
متن کاملHürthle (oncocytic) cell tumors of thyroid: etiopathogenesis, diagnosis and clinical significance.
The etiopathogenesis and the classification of oncocytic (Hürthle cell) tumors of the thyroid is reviewed with an emphasis on the role played by mitochondrial and nuclear genetic abnormalities that interfere with mitochondrial function. Oxyphilia is classified into primary or secondary and the so-called Hürthle cell carcinoma is divided into oncocytic (Hürthle cell) variants of papillary and fo...
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Oncocytic cell tumors are characterized by the accumulation of morphologically abnormal mitochondria in their cells, suggesting a role for abnormal mitochondrial biogenesis in oncocytic cell transformation. Little is known about the reason for the dysmorphology of accumulated mitochondria. The proteins regulating the morphology of mitochondria, the "mitochondria-shaping" proteins, can modulate ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/37997